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| Symbol | Value | Change | Percentage Change |
|---|---|---|---|
| DJIA | 11,632.38 | 29.88 | 0.26% |
| NASDAQ | 2,325.88 | 21.92 | 0.95% |
| S&P 500 | 1,282.19 | 5.19 | 0.41% |
| Date | Insider | Type | Ownership | Market Value | Shares | Price range | Total Holdings |
|---|---|---|---|---|---|---|---|
| 03/25/08 | SANDERLING VENTURE PARTNERS IV L P, Beneficial Owner of more than 10% of a Class of Security | Exercise of Stock Options | Indirect | $0.00 | 357,461 | $0.00 - $0.00 | 357,461 |
| 03/25/08 | SANDERLING VENTURE PARTNERS IV L P, Beneficial Owner of more than 10% of a Class of Security | Exercise of Stock Options | Indirect | $0.00 | 1.4 M | $0.00 - $0.00 | 525,373 |
| 03/25/08 | SANDERLING VENTURE PARTNERS IV L P, Beneficial Owner of more than 10% of a Class of Security | Exercise of Stock Options | Indirect | $391,954.50 | 689,157 | $0.00 - $3.50 | 689,158 |
| 03/25/08 | MIDDLETON FRED A, Director and Beneficial Owner of more than 10% of a Class of Security | Exercise of Stock Options | Indirect | $153,842.50 | 1.68 M | $0.00 - $3.50 | 1.76 M |
| 03/25/08 | MIDDLETON FRED A, Director and Beneficial Owner of more than 10% of a Class of Security | Exercise of Stock Options | Indirect | $238,112.00 | 776,084 | $0.00 - $3.50 | 960,688 |
| 03/25/08 | GUIDANT INVESTMENT CORP, Beneficial Owner of more than 10% of a Class of Security | Sale | Direct | $27.00 M | 1.5 M | $18.00 - $18.00 | 787,873 |
| 03/25/08 | GUIDANT INVESTMENT CORP, Beneficial Owner of more than 10% of a Class of Security | Exercise of Stock Options | Direct | $443,194.50 | 2.29 M | $0.00 - $3.50 | 787,873 |
| 03/25/08 | SWEENEY JAMES M, Officer and Director | Exercise of Stock Options | Indirect | $0.00 | 505,795 | $0.00 - $0.00 | 1.1 M |
| 03/25/08 | PRYSTOWSKY ERIC N, Director | Exercise of Stock Options | Direct/Indirect | $0.00 | 15,809 | $0.00 - $0.00 | 59,809 |
| 03/25/08 | REIN HARRY T, Director | Exercise of Stock Options | Indirect | $97,986.00 | 627,597 | $0.00 - $3.50 | 627,597 |
